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This phenomenon may be the result of competition between erythromycin and lincomycin for the ribosomal binding site.

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Many drugs besides salmeterol may affect the heart rhythm qt prolongation , including amiodarone, dofetilide, pimozide, procainamide, quinidine, sotalol, macrolide antibiotics such as erythromycin , among others.

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Co-administration of moderate cyp 3a4 inhibitors such as erythromycin 500mg orally three times a day and salmeterol 50 micrograms inhaled twice daily in 15 healthy subjects for 6 days resulted in a small but non-statistically significant increase in salmeterol exposure 1.

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But in terms of gram positive activity, clarithromycin is much better than erythromycin and azithromycin.

Antiarrhythmics medicines to treat abnormal heart beats , eg amiodarone , procainamide , disopyramide , sotalol the antihistamines astemizole , mizolastine or terfenadine arsenic trioxide atomoxetine certain antidepressants, eg amitriptyline , imipramine , maprotiline certain antimalarials, eg halofantrine , chloroquine , quinine , mefloquine , riamet certain other antipsychotics, eg thioridazine , haloperidol , sertindole , pimozide cisapride dronedarone droperidol intravenous erythromycin or pentamidine methadone moxifloxacin saquinavir.

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This can lead to cross-resistance between erythromycin, other macrolides, lincosamides, and streptogramin b, as they share a common binding site on the ribosome and this pattern of resistance is known as the mlsb phenotype.

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